منابع مشابه
Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
Vaccines have shown great success in treating and preventing tumors and infections, while adjuvants are always demanded to ensure potent immune responses. Polyethylenimine (PEI), as one of the well-studied cationic polymers, has been used as a transfection reagent for decades. However, increasing evidence has shown that PEI-based particles are also capable of acting as adjuvants. In this paper,...
متن کاملMicelle-Based Adjuvants for Subunit Vaccine Delivery
In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit va...
متن کاملNovel Vaccine Adjuvants
Vaccines still remain the most successful method for protection and eradication against diseases. However, to avoid harmful effects associated with whole organism vaccines, new vaccine candidates are composed of parts of an organism, and therefore these are weakly immunogenic. Adjuvants are essential components of vaccines that nonspecifically stimulate the immune system, particularly the innat...
متن کاملVaccine Adjuvants Revisited
A huge amount of evidence has been made available on various adjuvants as immunological auxiliaries. Very few of them, however, have made it into commercial vaccines. Their defining properties and uses are discussed in the following mini-review. WHAT IS AN ADJUVANT? In Freund's words [1] an adjuvant should “evoke very abundant serum antibody production sustained for an unexpectedly long time”. ...
متن کاملMucosal vaccine adjuvants update
Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry. Mucosal vaccines can offer lower costs, better accessability, needle-free delivery, and higher capacity of mass immunizations during pandemics. However, only very limited number of mucosal vaccines...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2013
ISSN: 2164-5515,2164-554X
DOI: 10.4161/hv.24829